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Paper | Regular issue | Vol 34, No. 5, 1992, pp.911-914
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5919
A New Synthesis of 1-Hydroxyisoindoles

Jean-Michel Vierfond,*Christian Martin, Yvette Mettey, Annick Reynet, and Marcel Miocque

*Laboratoire de Chimie Organique GREAM, Faculté de Pharmacie, 14 rue du Jardin des Plantes, POITIERS 86034, France


Heteroarylmethylation of halogenobenzonitriles in the presence of air (O2) gives 1-hydroxy-3-oxo-1-aryl-1H,3H-isoindoles in liquid ammonia. A "one-pot" or two-step synthesis is described and a mechanism is proposed.