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Paper | Regular issue | Vol 34, No. 4, 1992, pp.729-737
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5953
One Step Synthesis of 5-Bromo-2-chloro-6-hydroxy-4-[N-(2,3-dibromopropyl)-N-alkylamino]pyrimidines, Useful Intermediates for the Preparation of Pteridine Derivatives and Related Analogues

Maurizio Botta,* Raffaele Saladino, and Rosario Nicoletti*

*Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Banchi di Sotto, 55, 53100 Siena, Italy

Abstract

A simple synthesis of pteridine derivatives (12) and (13), 5-oxapteridines (10a-c) and 5-thiapteridine (15) via cyclization of the highly functionalized pyrimidinones (8a-c) is reported.