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Communication | Special issue | Vol 33, No. 1, 1992, pp.17-20
Published online, 1st January, 1970
DOI: 10.3987/COM-91-S1
Asymmetric Synthesis of Piperidine Alkaloids Utilizing Diastereoselective Reaction of 1,3-Oxazolidine with Grignard Reagents

Kimio Higashiyama,* Keiji Nakahata, and Hiroshi Takahashi

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


A facile method of synthesizing enantiomerically pure piperidine alkaloids, (R)-(-)-coniine and (2R,6S)-(-)-dihydropinidine, has been explored by employing the highly diastereoselective reaction of a 1,3-oxazolidine with Grignard reagents.