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Communication | Special issue | Vol 33, No. 1, 1992, pp.143-146
Published online, 1st January, 1970
DOI: 10.3987/COM-91-S58
Synthesis of (6S,8R)-6-(1'-Hydroxyethyl)carbopenem, a Thienamycin Type

Tomohisa Ohta, Sojiro shiokawa, Eiichiro Iwashita, Nobuaki Sato, Kuniya Sakurai, Takashi Ineyama, Hiroyuki Izawa, Kunisuke Izawa, and Shigeo Nozoe*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Title carbapenem (1) having thienamycin-type of side chain at C-6 was synthesized from L-glutamic acid. Chirospecific oxymercuration of 6-vinylcarbapenam (12a) successfully induced 8R -hydroxyl.