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Communication | Regular issue | Vol 34, No. 4, 1992, pp.667-674
Published online, 1st January, 1970
DOI: 10.3987/COM-92-5974
Annoreticuin and Isoannoreticuin: Two New Cytotoxic Acetogenins from Annona reticulata

Yang-Chang Wu,* Fang-Rong Chang, Chang-Yi Duh, and Shang-Kwei Wang

*Natural Products Research Center and School of Pharmacy, Kaohsiung Medical College, Kaohsiung 80708, Taiwan, R.O.C.


Two novel bioactive monotetrahydrofuran acetogenins, annoreticuin (1) and isoannoreticuin (2), have been isolated from the leaves of Formosan plant Annona reticulata L. (Annonaceae). The plane structures of these two new compounds were elucidated on the basis of 1H and 13C nmr data and by mass spectrometry. These two compounds showed selective cytotoxic activities for certain human tumor cell lines.