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Communication | Regular issue | Vol 34, No. 6, 1992, pp.1097-1100
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6036
A Novel and Efficient Synthesis of 9-(c-4,t-5-Bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) Having Anti-HIV Activity from Norbornadiene

Nobuya Katagiri,* Hiroshi Sato, Sachie Arai, Akemi Toyota, and Chikara Kaneko

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan

Abstract

9-(c-4, t-5-Bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA: 1), a novel carbocyclic nucleoside having significant anti-HIV activity, has been synthesized from norbornadiene.