Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 34, No. 8, 1992, pp.1515-1518
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6098
Enantioselective Synthesis of Indolizidine Alkaloid: A Formal Total Synthesis of (-)-Pumiliotoxin 251D

Toshio Honda,* Michiyasu Hoshi, and Masayoshi Tsubuki

*Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan

Abstract

An enantioselective formal total synthesis of (-)-pumiliotoxin 251D was achieved by employing the Sharpless kinetic resolution of the 2-furylmethanol derivative (3) and a stereoselective radical cyclisation of the thiocarbonylimidazolide (10) as key steps.