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Communication | Regular issue | Vol 34, No. 8, 1992, pp.1515-1518
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6098
Enantioselective Synthesis of Indolizidine Alkaloid: A Formal Total Synthesis of (-)-Pumiliotoxin 251D

Toshio Honda,* Michiyasu Hoshi, and Masayoshi Tsubuki

*Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan


An enantioselective formal total synthesis of (-)-pumiliotoxin 251D was achieved by employing the Sharpless kinetic resolution of the 2-furylmethanol derivative (3) and a stereoselective radical cyclisation of the thiocarbonylimidazolide (10) as key steps.