Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 36, No. 6, 1993, pp.1337-1349
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6316
Synthesis of Pyrazino[1,2-a:4,5-a’]di[1,8]naphthyridine and Pyrazino[1,2-a][1,8]naphthyridines

Vicente Ojea and José Ma Quintela*

*Departamento de Química Fundamentale Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateria, s/n, E-15071, La Coruña, Spain

Abstract

A series of 3-alkyl-, 3-aryl- and 3-hetarylhexahydro-1H-pyrazino[1,2-a][1,8]naphthyridines (4) were prepared from 2-(4-substituted 1-piperazinyl)-3-formylpyridines (2) by condensation with malononitrile and subsequent thermal cyclization. Octahydro[1,2-a:4,5-a’]di[1,8]naphthyridine (7) was also obtained.