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Paper | Regular issue | Vol 36, No. 7, 1993, pp.1521-1528
Published online, 1st January, 1970
DOI: 10.3987/COM-92-6318
A Simple Method for Synthesis of 4-Dimethylamino-2,6-dimethyl-5-phenylpyrimidines

Wojciech Zielinski* and Monika Mazik

*Instiute of Organic Chemistry and Technology, Silesian University of Technology, ul. Krzywoustego 4, 44-101 Gliwice, Poland

Abstract

The reaction of N-(1-methyl-2-phenylvinyl)acetimidoyl chloride and its derivatives substituted at the benzene ring with N,N-dimethylcyanamide was studied. At the first stage, linear products like 1-chloro-1-dimethylamino-3,5-dimethyl-6-phenyl-2,4-diaza-1,3,5-hexatrienes were obtained. They underwent cyclization to 4-dimethylamino-2,6-dimethyl-5-phenylpyrimidines in alkaline medium at elevated temperature.