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Paper | Regular issue | Vol 36, No. 6, 1993, pp.1399-1410
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6343
An Alternative Method for Synthesis of the CC-1065 Pharmacophore, 1,2,7,7a-Tetrahydrocycloprop[1,2-c]indol-4-one

Yuqiang Wang and J. William Lown*

*Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada

Abstract

The synthesis of the CC-1065 pharmacophore, 2-(1-methylpyrrole-2-carbonyl)-1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (17), is described. The methods reported here provide an alternative route for the synthesis of compounds possessing the biologically active 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) functionality.