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■ Synthetic Applicatons of 2-Aryl-4-piperidones. IX. Synthesis of Pyrido[1’,2’:1,2]imidazo[4,5-a]quinolizidin-2-one

Anna Diez, Sylvie Mavel, Jean-Claude Teulade, Olivier Chavignon, Marie-Eve Sinibaldi, Yves Troin, and Mario Rubiralta*

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain

Abstract

The synthesis of the new heterocyclic compound pyrido[1’,2’:1,2]imidazo[4,5-a]quinolizidin-2-one (1), an aza analog of indolo[2,3-a]quinolizidin-2-one, has been effected infour steps from an appropriate 2-aryl-4-piperidone (2), including closure of ring C as the key step.