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Paper | Regular issue | Vol 36, No. 9, 1993, pp.2035-2050
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6406
Synthesis of (2R, 3S,4R)-3,4-Dihydroxy-2-hydroxymethylpyrrolidine and (2S,3R,4S,5S)-3,4-Dihydroxy-2,5-dihydroxymethylpyrrolidine from (R)-Serine and D-Ribonolactone

Nobuo Ikota

*National Institute of Radiological Sciences, 9-1, Anagawa-4-Chome, Inage-ku, Chiba 263-0024, Japan

Abstract

(2R,3S,4R)-3,4-Dihydroxy-2-hydroxymethylpyrrolidine derivative (9, 10) and (2S,3R,4S,5S)-3,4-dihydroxy-2,5-dihydroxymethylpyrrolidine derivatives (16, 17) were synthesized stereoselectively from (R)-serine and D-ribonolactone, respectively.