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Paper | Regular issue | Vol 36, No. 9, 1993, pp.2129-2137
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6433
An Efficient Synthesis of New Phenylpyrrolizine and Phenylpyrrolopyrazine Derivatives

Olivier Norbert Tembo, Patrick Dallemagne, Sylvain Rault, and Max Robba*

*Centre d’Etudes et de Recherch sur le Medicament de Normandie, U. F. R. des Sciences Pharmaceutiques, 1, rue Vaubénard, 14032 Caen Cedex, France

Abstract

Synthesis of new 3-phenyl-2,3-dihydro-1H-pyrrolizine derivatives is achieved starting from 3-amino-3-phenylpropionic acid via an iminium salt. The reactivity of this system is studied and the new 4-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-one derivatives are synthesized, via a Beckmann’s rearrangement.