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Communication | Regular issue | Vol 36, No. 11, 1993, pp.2441-2444
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6508
A Facile One-Pot Synthesis of 5-Trifluoromethyl- and 5-Perfluoroalkyloxazoles from N-Alkyl-N-acylamino Acids

Masami Kawase

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan


The reaction of N-acyl-N-benzyl-α-amino acids with trifluoroacetic or perfluorocarboxylic anhydride in the presence of pyridine affords 5-trifluoromethyl- or 5-perfluoroalkyloxazoles in high yields.