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Paper | Regular issue | Vol 38, No. 2, 1994, pp.333-344
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6556
New 5-Substituted Derivatives of Ethyl 2,3-Dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate

Victor Martinez-Merino,* Maria J. Gil, Alberto Gonzalez, Jose M. Zabalza, Javier Navarro, and Maria A. Mañu

*Departamento de Quimica, Universidad Publica de Navarra, 31006 Pamplona, Spain

Abstract

New series of ethyl 5-substituted 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate was prepared either a) directly by reaction of 5-substituted 2-chlorothio-3-pyridinecarbonyl chlorides with ethyl glycinate or b) by oxidation of the correspondent 2-mercapto-3-pyridinecarboxamides. New 5-substituted 1,2-dihydro-2-thioxo-3-pyridinecarboxylic acids as starting materials are described.