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■ Syntheses of 2,4-Diaminopyrimidines and 1-Aminoisoquinolines in the Reactions of Alkyl and Benzyl Ketones with Cyanamide and N,N-dimethylcyanamide

Wojciech Zielinski* and Monika Mazik

*Instiute of Organic Chemistry and Technology, Silesian University of Technology, ul. Krzywoustego 4, 44-101 Gliwice, Poland

Abstract

The reaction of alkyl and benzyl ketones with cyanamide and N,N-dimethylcyanamide in the presence of POCl₃ was examined. At the first stage, chloroformamidine derivatives were formed. In the presence of TiCl₄, they underwent further reactions to the derivatives of 1-aminoisoquinoline and 2,4-diaminopyrimidine. The effect of a constitution of substrates on adequate ratios of heterocyclic compounds is discussed.