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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Paper | Regular issue | Vol 38, No. 2, 1994, pp.391-397
Published online, 1st January, 1970■ Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6587
■ Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives
Christian Rivalle* and Emile Bisagni
*URA 1387 CNRS, Section de Biologie Batiments 110-112, Institut Curie, 15 Rue Georges Clemenceau 91405 Orsay, France
Abstract
9-Methoxy-5,11-dimethyl-(and 5-methyl)-6H-pyrido[4,3-b]carbazole-1-carbonitriles (8) were synthesized through methoxyellipticine N-oxides (4) and subsequent deoxygenation-functionalization by diethyl cyanophosphonate. Hydration of these nitriles (8) into 1-carboxamidoellipticines (9) and cytotoxicities of these last compounds are also reported.
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