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Paper | Regular issue | Vol 38, No. 2, 1994, pp.391-397
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6587
Synthesis of 9-Methoxyellipticine N-Oxide and Its Transformation into 1-Functionalized Ellipticine Derivatives

Christian Rivalle* and Emile Bisagni

*URA 1387 CNRS, Section de Biologie Batiments 110-112, Institut Curie, 15 Rue Georges Clemenceau 91405 Orsay, France


9-Methoxy-5,11-dimethyl-(and 5-methyl)-6H-pyrido[4,3-b]carbazole-1-carbonitriles (8) were synthesized through methoxyellipticine N-oxides (4) and subsequent deoxygenation-functionalization by diethyl cyanophosphonate. Hydration of these nitriles (8) into 1-carboxamidoellipticines (9) and cytotoxicities of these last compounds are also reported.