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Communication | Regular issue | Vol 38, No. 2, 1994, pp.281-282
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6604
Reactivity of the Pyridylthiosilyl Enol Ether — Route to β-Lactone and β-Lactam —

Koichi Hirai,* Hiroshi Homma, and Isamu Mikoshiba

*New Lead Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


A simple and facile method for β-lactone and β-lactam syntheses based on a Lewis acid promoted pyridylthiosilyl enol ether (1) addition to an aldehyde or Schiff base is described.