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■ Synthetic Studies towards a trans-3,4-Diamine Derivative of Piperidine Mimicking Buspirone

Shikai Zhao, Arun Ghosh, Stan V. D'Andrea, Jeremiah P. Freeman, Philip F. VonVoigtlander, Donald B. Carter, Martin W. Smith, James. R. Blinn, and Jacob Szmuszkovicz*

*Department of Chemistry and Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN 46556, U.S.A.

Abstract

Based on modeling experiment of buspirone we synthesized the sterically restricted analog, namely the piperidine 3,4-trans-amino amide (3). Preliminary biological evaluation is reported.