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Paper | Special issue | Vol 39, No. 1, 1994, pp.163-170
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S(B)12
Synthetic Studies towards a trans-3,4-Diamine Derivative of Piperidine Mimicking Buspirone

Shikai Zhao, Arun Ghosh, Stan V. D'Andrea, Jeremiah P. Freeman, Philip F. VonVoigtlander, Donald B. Carter, Martin W. Smith, James. R. Blinn, and Jacob Szmuszkovicz*

*Department of Chemistry and Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN 46556, U.S.A.


Based on modeling experiment of buspirone we synthesized the sterically restricted analog, namely the piperidine 3,4-trans-amino amide (3). Preliminary biological evaluation is reported.