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Paper | Special issue | Vol 39, No. 1, 1994, pp.133-138
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S(B)6
Structure Determination of a Geometric Isomer of 2-Acetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-methylpropylidene)isoquinoline

Tozo Fujii,* Masashi Ohba, Naoko Fukui, and Tadamasa Date

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


A geometric isomer (mp 112-113°C) of 2-acetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-methylpropylidene)isoquinoline (4), prepared previously from 3,4-dihydro-6,7-dimethoxy-1-(2-methylpropyl)isoquinoline (3) by acetylation with acetic anhydride and pyridine, has been shown to have the E configuration (4a) by means of 1H nmr spectroscopic and X-ray crystallographic analyses.