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■ Structure Determination of a Geometric Isomer of 2-Acetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-methylpropylidene)isoquinoline

Tozo Fujii,* Masashi Ohba, Naoko Fukui, and Tadamasa Date

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

A geometric isomer (mp 112-113°C) of 2-acetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-methylpropylidene)isoquinoline (4), prepared previously from 3,4-dihydro-6,7-dimethoxy-1-(2-methylpropyl)isoquinoline (3) by acetylation with acetic anhydride and pyridine, has been shown to have the E configuration (4a) by means of ¹H nmr spectroscopic and X-ray crystallographic analyses.