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■ A Practical and General Synthesis of (+)-Carboxyalkyldeoxoartemisinis

Mankil Jung,* Antonio C. C. Freitas, James D. McChesney, and Hala N. ElSohly

*Research Institute of Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, U. S. A.

Abstract

Dye-sensitized photoxygenation of olefinic alcohols of dihydroartemisinates (4a-c) and direct oxidation of olefinic deoxoartemisinins (5a-c) have led to the preparation of carboxyalkyldeoxoartemisinins (6a-c), which are water-soluble and chemically more stable antimalarial agents.