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Paper | Special issue | Vol 37, No. 2, 1994, pp.815-822
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S66
An Unusual Aromatization of Hantzsch-Type 4-Antipyryl-1,4-dihydropyridines

Jean-Jacques Vanden Eynde,* Annie Mayence, André Maquestiau, and Ernst Anders

*Organic Chemistry Laboratory, University of Mons-Hainaut, Place du Parc 20, B-7000 Mons, Belgium

Abstract

Under acidic conditions, Hantzsch-type 4-antipyryl-1,4-dihydropyridines undergo an elimination of the 4-substituent to yield 4-unsubstituted pyridines and antipyrine. The mechanism and the scope of the reaction are discussed.