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Paper | Regular issue | Vol 38, No. 5, 1994, pp.1119-1125
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6685
A New Route to Antibacterial Trimethoprim

Kenichi Harada, Tominari Chosi, Eiichi Sugino, Kohichi Sato, and Satoshi Hibino*

*Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan


3-Methylthio-2-(3‘,4‘,5‘-trimethoxybenzyl)acrylonitrile (6) derived from 3,4,5-trimethoxyphenylacetaldehyde (2) in a four step sequence was utilized as a new three carbon unit of trimethoprim (1).