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Paper | Regular issue | Vol 41, No. 2, 1995, pp.267-276
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6862
Hypotensive Constituents from the Bark of Holarrhena pubescens (Holarrhena antidysenterica)

Bina Shaheen Siddiqui*, Shahid Bader Usmani, Sabira Begum, Salimuzzaman Siddiqui, Khalid Aftab, and Anwar-ul-Hassan Gilani

*H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract

Two new alkaloids of conanine series, holamide (N-(N’-methylacetamido)-3-oxo-1,4-conadiene) (1), pubescinine (11α-acetoxy-N-demethyl-3-oxo-1,4,17(20)-conatriene) (2) and a known alkaloid norconessine (3-N-methylamino-5-conanene) (3), have been isolated from the bark of Holarrhena pubescens Buch. Ham (Holarrhena antidysenterica Linn.) (Apocynacea). Their structures have been established through spectroscopic studies. Both 1 and 2 showed hypotensive activity in rats at a does of 3 mg/kg.