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Paper | Regular issue | Vol 41, No. 1, 1995, pp.87-94
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6887
1',2',6'-Thiadiazine 1',1'-Dioxide and Imidazo [4',5'-c][1',2',6']thiadiazine 2',2'-Dioxode 1,3-Oxathiolane Nucleoside Analogues: Synthesis and Anti-HIV-1 Activity

Tibor Breining, Alex R. Cimpoia, Tarek S. Mansour*, Nick Cammack, Philippa Hopewell, and Claire Ashman

*BioChem Therapeutic Inc., 275 Armand-Frappier Boulevard Laval, Québec, Canada H7V 4A7

Abstract

A series of 1,3-oxathiolanes containing the 1,2,6-thiadiazine dioxide moieties were synthesized by various coupling conditions of the oxathiolane sugar (3) and silylated 1,2,6-thiadiazine dioxides (4-7) as bases. The compounds were evaluated for their potential anti-HIV activities in MT-4 cells and were found to lack activity at 100 μg/ml.