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Communication | Regular issue | Vol 41, No. 1, 1995, pp.13-16
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6927
A Facile Preparation of β-Alky-β-phenylthio-α,β-unsaturated Carbonyl Compounds in a Synthesis of Alkyl Substituted Thiophene-2-carboxylic Esters

Hsi-Hwa Tso* and Yu-Jiun Chen

*Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan, R.O.C.


A facile two-step or three-step one-flask procedure for a synthesis of β-alkyl-β-phenylthio-α,β-unsaturated carbonyl compounds (3a-j) from readily prepared 3-methoxy-1-phenylthio-1-propyne (1) is described. Condensation of 3a-j with methyl thioglycolate readily affords a number of 3-alkyl- and 3,5-dialkylthiophene-2-carboxylic methyl esters.