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Paper | Regular issue | Vol 41, No. 3, 1995, pp.461-469
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6951
A Convenient Synthesis of Pyrido[3,2-b][1,4]bensothiazine Derivatives via Oxidative Ring Closure of 3-Substituted 6-[N-(2-Mercaptophenyl)]aminopyridines

Ji-Wang Chern* and Kuo-Rong Wu

*Medical Laboratories and Institute of Pharmacy, National Defense Medical Center, P.O. Box 90048-512, Taipei, Taiwan, R.O.C.

Abstract

3-Substituted pyrido[3,2-b][1,4]benzothiazines were prepared either by heating the disulfide derivatives, which were obtained by a treatment of 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines with diethyl azodicarboxylate (DEAD) or NBS in DMF at room temperature under the basic conditions or directly by heating the reaction mixture 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines.