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Paper | Regular issue | Vol 41, No. 5, 1995, pp.931-936
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6964
Synthesis of 17-Azacholesterol

Jacek W. Morzycki* and Zenon Lotowski

*Institute of Chemistry, University of Warsaw, Bialystock Branch, Al. Pilsudskiego 11/4, 15 443, Poland

Abstract

The synthesis of 17-azacholesterol from the N-(3-hydroxy-1-methylpropyl)-17-aza lactam is described. The starting alcohol was oxidized to aldehyde which was treated with isobutylmagnesium bromide. The secondary alcohol obtained was oxidized to ketone. Both ketone and lactam carbonyl groups were consecutively reduced to CH2.