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Communication | Regular issue | Vol 41, No. 3, 1995, pp.409-414
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6971
On the Chemistry of the 18-Deoxycytochalasin H, HIV-1 Protease Inhibitor, L-696,474. 2: Novel Ring Annulations

B. Moon Kim*, James P. Guare, and Steven M. Pitzenberger

*Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, U.S.A.

Abstract

Unprecedented annulation of the 11-membered ring portion of 18-deoxycytochalasin H, a 3μM inhibitor of HIV-1 protease, has been observed furnishing a novel tetracyclic cytochalasin (5). Subsequent desilylation of 5 provided yet another set of new tetracyclic cytochalasin derivatives.