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Paper | Regular issue | Vol 41, No. 3, 1995, pp.515-522
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6983
Pyrrolothieno[1,4]diazepines Part 1 : Synthesis and Study of the Reaction Pathway

Michel Boulouard, Sylvain Rault, Patrick Dallemagne, and Max Robba*

*Centre d’Etudes et de Recherche sur le Médicament de Normandie, U. F. R. des Sciences Pharmaceutiques, 1, rue Vaubénard, 14032 CAEN cedex, France

Abstract

Synthesis of 5,6-dihydro-4-oxo-4H-pyrrolo[1,2-a]thieno[3,2-f][1,4]diazepines is achieved starting from 2-(2-formyl-1H-pyrrol-1-yl)-3-thiophenecarbonitrile. Reaction pathway is demonstrated via isolation of intermediates involved in the synthetic reaction.