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Paper | Regular issue | Vol 41, No. 4, 1995, pp.781-788
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6997
Pteridines, CIV. Regioselective Alkoxylation of Pteridines at the 6-Position by N-Bromo-succinimide and Alcohol

Takashi Sugimoto and Wolfgang Pfleiderer

*Department of Natural Science Informatics, School of Informatics and Sciences, Nagoya University, Chikusa-ku, Nagoya 464-01, Japan

Abstract

Reaction of 1,3-dimethyllumazine with N-bromosuccinimide or bromine in an appropriate alcohol afforded 6-alkoxy-1,3-dimethyllumazine. N-Iodosuccinimide or iodine also brought about the same reaction. This procedure was applicable to other pteridine compounds, such as 2-dimethylamino-4(3H)-oxopteridine. The mechanism of this alkoxylation reaction is discussed.