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Communication | Special issue | Vol 39, No. 1, 1994, pp.67-72
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S(B)47
■ A Concise Enantiocontrolled Route to (+)-Patulolide C

Seiichi Takano*, Taku Murakami, Kiyohiro Samizu, and Kunio Ogasawara

*Pharnaceutical Institute, Tohoku University, Aramaki, Aoba-ku, sendai 980-8578, Japan

Abstract

A naturally occurring anti fungal macrolide (+)-patulolide C has been synthesized enantioselectively via the C2-symmetric bis-epoxide by incorporation of two molecular units of (R)-O-benzylglycidol.