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Communication | Special issue | Vol 40, No. 1, 1995, pp.119-122
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S26
Simple Syntheses of Lespedamine and 5-Bromo-N,N-dimethyltryptamine Based on 1-Hydroxyindole Chemistry

Masanori Somei, Kensuke Kobayashi, Keiko Tanii, Toshihiko Mochizuki, Yumiko Kawada, and Yashikazu Fukui

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Various types of 1-hydroxyindoles were prepared for the first time. Through methylation or acid catalyzed nucleophilic bromination of N,N-dimethyl-1-hydroxytryptamine, simple syntheses of lespedamine and 5-bromo-N,N-dimethyltryptamine were achieved, respectively.