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Paper | Regular issue | Vol 41, No. 6, 1995, pp.1207-1218
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7024
Preparation of Homologous Pyrazolonedicarboxylates

Janja Makarevic* and Vinko Skaric

*Laboratory of Stereochemistry and Natural Products, "Ruder Boskovic" Institute, 41001 Zagreb, P.O. B. 1016, Croatia

Abstract

Homologous disodium pyrazolonedicarboxylates (8, 16f and 16g) as possible protecors of cis-DDP induced nephrotoxicity, have been prepared by the reaction of hydrazine with di-t-butyl ethyl β-keto triesters (5b, 13b and 13c) and subsequent hydrolysis of formed di-t-butyl pyrazolonedicarboxylates (6b, 14b and 14c).