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Paper | Regular issue | Vol 41, No. 6, 1995, pp.1271-1274
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7054
Alkylation of 5-Cyanoimidazole-4-carboxamide

Peter K. Bridson* and Rekha V. Iyengar

*Department of Chemistry, The University of Memphis, Memphis, TN 38152, U.S.A.


Alkylation of 5-cyanoimidazole-4-carboxamide under alkaline conditions occurs with extremely high regioselectively at the nitrogen atom adjacent to the cyano group. The reaction is demonstrated to be useful for the synthesis of imidazo[1,5-a]pyrazines.