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Paper | Regular issue | Vol 41, No. 10, 1995, pp.2203-2219
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7128
6- Fluoro-7-(1-piperazinyl)quinoxaline 1,4-Dioxide. Part I. 2-(N-2-Hydroxyalkylcarbamoyl) Derivatives

Mustafa M. El- Abadelah,* Musa Z. Nazer, Naser S. El-Abadla, and Herbert Meier*

*Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, D-55099 Mainz, Germany

Abstract

A series of N-[6-fluoro-7-(4-methyl-1-piperazinyl)-3-methyl-2-quinoxaloyl]-β-aminoalkanol 1,4-dioxides (12a-h) have been synthesized for bioassay via the Beirut reaction of 5(6)-fluoro-6(5)-(4-methyl-1-piperazinyl)benzofuroxan (9) with the appropriate N-acetoacetyl-β-aminoalkanol in the presence of triethylamine. Preliminary in vitro investigations have indicated that none of the title compounds exhibits any significant antibacterial potency at concentrations ≤ 200 μg / ml.