HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Synthesis and Stereochemistry of Chiral 1,3-Dioxanic Compounds Obtained from α-Alkylated β-Ketoesters

Ion Grosu* , Sorin Mager, Gérard Plé, Roberto Martinez, Luminita Muntean, and Eugen Mesaros

*Instituto de Química, Universidad Nacional Autónama de México, Ciudad Universitaria, Circuito Exterior, Mexico D.F., 04510, Mexico

Abstract

1,3-Dioxanic compounds were obtained by the ketalisation reaction of some α-alkylated β-ketoesters. The conformational analysis by means of ¹H- and ¹³C-nmr investigations showed the anancomeric structure of the compounds. The axial or the equatorial position of the groups was inferred by N.O.E. experiments. The influence of the chiral carbon atom of the esteric group located at C² was studied using the diastereotopicity of the protons and of the carbon atoms recorded in high field nmr spectra.