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Paper | Regular issue | Vol 41, No. 10, 1995, pp.2251-2262
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7163
Polycyclic N-Heterocyclic Compounds. 47 Synthesis and Evaluation of Anti-Platelet Aggregation Activity of 11,13,15-Triazasteroid and Related Compounds

Kenji Sasaki, Tomohiro Funabashi, Hiromi Ohtomo, Taiji Nakayama, and Takashi Hirota*

*Faculty of Pharmaceutical Science, Okayama University, 1-1-1 Tsushima-Naka, Okayama 700, Japan

Abstract

Synthesis and separation of cis- and trans-1,2,4,5,5a,6,7,8,9,9a-decahydrobenz[h]imidazo[1,2-c]quinazolines and its precursors are described. Inhibitory activity against collagen-induced platelet aggregation for rabbit blood of these compounds and their benzologues at A ring is also evaluated.