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Communication | Special issue | Vol 42, No. 1, 1996, pp.99-104
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S30
Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge 5. A Highly Concise and Efficient Synthesis of the C37~C54 Tricyclic JKL-Ring Part

Kiyoshi Horita, Shun-ichiro Hachiya, Kazuhito Ogihara, Yutaka Yoshida, Masaaki Nagasawa, and Osamu Yonemitsu

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

Abstract

A concise and efficient synthesis of C37~C54 tricyclic JKL-ring unit (2) of halichondrin B (1) utilizing C2-symmetric spiroketal derivative (5) as a synthetic key intermediate, easily provided from dimethyl L-(+)-tartrate, is reported.