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Paper | Regular issue | Vol 43, No. 4, 1996, pp.891-898
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7396
Convenient Synthesis of Fragment E of Antibiotic, Nosiheptide

Chung-gi Shin *, Yasuhiro Yamada, Keiichiro Hayashi, Yasuchika Yonezawa, Kazuyuki Umemura, Tsuyoshi Tanji, and Juji Yoshimura

*Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University, Rokkakubashi, Kanagawa-ku, Yokohama 221, Japan


A convenient synthesis of Fragment E, 4-hydroxymethyl-3-methylindole-2-carboxylic acid (1), from 2-methyl-3-nitrobenzyl alcohol through six steps conversion in 32% overall yield is described.