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Paper | Regular issue | Vol 43, No. 10, 1996, pp.2099-2112
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7439
A Convenient Access to Protoberberine Derivatives

Imanol Tellitu, Dolores Badía, Esther Domínguez, and Luisa Carrillo

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Pais, Vasco, P.O. Box 644, 48080-Bilbao, Basque Country, Spain


A synthesis of protoberberine derivatives starting from (1R*,3S*,4R*)-3-aryl-1-methyl-4-silyloxytetrahydroisoquinolines is presented. The influence of the substitution pattern of the aryl ring at C-3 and the effect of the derivatization of the hydroxyl group at C-4 on the final cyclization reaction is discussed.