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Paper | Regular issue | Vol 43, No. 9, 1996, pp.1923-1926
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7514
A Mild Preparation of 2,6-Piperidinediones

Jiarong Zhu, Pham Huy Choung, Pascale Lemoine, Alain Tomas, and Hervé Galons

*Laboratoire de Chimie Therapeutique, Faculte de Pharmacie, 4 avenue de l'Observatoire75270 Paris Cedex 06, France

Abstract

Substituted glutaric acids reacted with alkyloxyamines in the presence of N-ethyl-N-dimethylaminopropylcarbodiimide hydrochloride to form 1-alkyloxy-2,6-piperidinediones. The protecting group on the nitrogen was easily removed in high yield. This process is exemplified by the preparation of aminoglutethimide.