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Paper | Regular issue | Vol 45, No. 3, 1997, pp.475-481
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7688
Synthesis of Isovincadine and 16-Epiisovincadine, Analogs of Vincadine and 16-Epivincadine with a New Rearranged Skeleton, from a Vincadifformine Derivative

Guy Lewin* and Corinne Schaeffer

*Laboratoire de Pharmacognosie, Faculté de Pharmacie, 5, Rue, Av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France


Treatment of the rearranged indole alkaloid (3) under reductive conditions [a) hydrogenolysis; b) NaBH3CN in AcOH] provided 16-epiisovincadine (6) and isovincadine (7), two new rearranged analogs of the alkaloids 16-epivincadine (9) and vincadine (10).