Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 45, No. 5, 1997, pp.897-910
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7696
A Novel Method of Preparation of 3-Acylimidazo[1,2-a]pyridines

Jean-Luc Moutou, Martine Schmitt, Valérie Collot, and Jean-Jacques Bourguignon*

*Laboratoire de Pharmacochimie Moleculaire, Faculte de Pharmacie, ULP, 74, route du Rhin 67401 ILLKIRCH Cedex, France

Abstract

A series of 2-substituted 3-acylimidazo[1,2-a]pyridines were synthesized in good to moderate yields from secondary amidino ketones and bromine in acetic acid. Cyclocondensation of the α-bromo-β-amidino ketones (6) led to the corresponding trans-dihydroimidazoles (13), which may yield spontaneously the stable 3-acylimidazo[1,2-a]pyridines (2) after dehydrogenation.