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Paper | Regular issue | Vol 45, No. 3, 1997, pp.501-506
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7705
Synthesis of 4-[(8-Amino-6-benzyl-10(9H)-oxo-4,5-dihydro-(6H)-isoxazolo[4,3-d]pyrimido[4,5-b]azepin-3-yl]benzoyl-L-glutamic Acid. A Novel Pyrimidoazepine-based Folic Acid Derivative

Michael L. Miller and Partha S. Ray*

*Department of Chemistry, The University of Memphis, Memphis, Tennessee 38152, U.S.A.


Synthesis of the titled compound (13) is described using an intramolecular 1,3-dipolar cycloaddition reaction as the key step.