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Communication | Regular issue | Vol 45, No. 3, 1997, pp.435-438
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7734
Synthetic Study Directed toward Novel Multi-Linked Heterocycles1

Masanori Somei,* Yoshikazu Yamada, Keiichi Kitagawa, Katsuko Sugaya, Yayoi Tomita, Fumio Yamada, and Kyoko Nakagawa

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


2-Amino-4-(1-methylindol-3-yl)thiazole (11c) has a characteristic nucleophilic nature at the 5-position and add to the 4-position of acetylpyridinium acetate (13) producing 2-acetylamino-5-(1-acetyl-1,4-dihydropyridin-4-yl)-4-(1-methylindol-3-yl)thiazole (1c). Its structure was established by X-ray single crystallographic analysis. Applying the results, simple syntheses of the related tris- (1a-b and 2-8) and tetrakis-linked heterocycles (9) were achieved.