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Communication | Regular issue | Vol 45, No. 5, 1997, pp.835-839
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7764
C2-Alkylaminopenem Synthesis

Takumi Yamasaki, Hiroshi Kadoi, and Isao Nagakura*

*Chemical Process Development Laboratory, Drug Substance Manufacturing Plant, Pfizer Pharmaceuticals, 5-Gochi, Taketoyo-cho, Chita-gun, Aichi, Japan

Abstract

A simple synthesis of C2-dialkylaminopenems is described. Azetidione glyoxylate has been cyclized to C2-aminopenem, via an intramolecular sulfide-contraction reaction.