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Paper | Regular issue | Vol 45, No. 9, 1997, pp.1723-1732
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7859
Studies on the Synthesis of Substituted 3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines as Non-peptide Scaffolds for Peptidomimetics

Mercedes Martín-Martínez, Ma Teresa García-López, Rosario Herranz, and Rosario González-Muñiz*

*Instituto de Química Médica, C. S. I. C., Calle Juan de Cierva, 3, E-28006 Madrid, Spain


Intramolecular reductive amination of 4-keto diesters, derived from Z-Xaa-Yaa dipeptides, and subsequent γ-lactamization is a versatile method for the preparation of 3,6-dioxoperhydropyrrolo[1,2-a]pyrazines bearing amino acid side chains at C-1, C-4 and C-7 positions, as Xaa-Yaa-Zaa (Yaa ≠ Gly) tripeptide mimetics.