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Note | Regular issue | Vol 45, No. 9, 1997, pp.1825-1831
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7880
Cyclocondensation of Cyanohydrins with Aldehydes or Ketones

Jean-François Stambach,* Louis Jung, and Raymond Hug

*Laboratoire de Chimie Thérapeutique, Université Louis Pasteur, U.F.R. des Sciences Pharmaceutiques, 74, route du Rhin, BP 24, 67401 ILLKIRCH Cedex, France


Cyanohydrins (1) are easily condensed with aldehydes or ketones (2) in anhydrous strong acidic conditions to give 1,3-oxazolidin-4-ones (3a-i) in good yields. The mechanism of this cyclocondensation is discussed.