Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 45, No. 10, 1997, pp.1967-1978
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7931
Synthesis and Aromatization of Dihydropyrimidines Structurally Related to Calcium Channel Modulators of the Nifedipine-Type

Jean Jacques Vanden Eynde, Nancy Audiart, Valérie Canonne, Sophie Michel, Yves Van Haverbeke, and C. Oliver Kappe*

*Institute of Organic Chemistry, Karl-Franzens-University Graz, Heinrichstr. 28, A-8010 Graz, Austria

Abstract

A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.